Genotoxic Effects of Exposure to Gasoline Fumes on Petrol Pump Workers

Amrin Shaikh, Darshana Barot, Divya Chandel

Abstract


Background: Petrol pump workers are occupationally exposed to gasoline and its fumes consisting of several mutagenic chemicals.

Objective: To evaluate the genotoxic effects of exposure to gasoline fumes on petrol pump workers.

Methods: The study groups included 70 petrol pump workers (exposed group) and 70 healthy age-matched individuals with no known exposure (comparison group). Buccal micronucleus cytome assay (BMCyt) was performed to check the genotoxicity caused due to inhalation of gasoline fumes.

Results: The frequencies of micronucleated cells, nuclear bud, condensed chromatin cells, karyorrhectic cells, pyknotic cells, and karyolytic cells were significantly higher in the exposed workers compared to the comparison group.

Conclusion: Exposure to gasoline fumes is associated with increased frequency of cell abnormalities. This may lead to various health consequences including cancer in those occupationally exposed to gasoline fumes.


Keywords


Gasoline; Occupational exposure; Mouth; DNA damage; Micronucleus tests; Biomarkers



doi: 10.15171/ijoem.2018.1159


 pISSN: 2008-6520
 eISSN: 2008-6814

Creative Commons LicenseThis work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License