Effects of delta-Aminolevulinic Acid Dehydratase Gene Polymorphism on Hematological Parameters and Kidney Function of Lead-exposed Workers

Mona Sobhi Siha, Dalia Abdel-Hamid Shaker, Hebatalla Saad Teleb, Laila Ahmed Rashed

Abstract


Lead exposure is associated with several health hazards among workers with different individual responses. We conducted this study to determine the possible effects of lead exposure on hematological parameters and kidney function of a group of Egyptian ammunition workers and the interaction of aminolevulinic acid dehydratase (ALAD) G177C gene polymorphisms as an effect modifier. Significant differences were observed between exposed workers with ALAD1-1 and ALAD1-2 genotypes in terms of blood lead level, hematological parameters and kidney function. It seems that δ-ALAD gene polymorphism may be an effect modifier and a marker of genetic susceptibility to lead toxicity.

Keywords


Explosive agents; Lead; Porphobilinogen synthase; Polymorphism, genetic; beta 2-Microglobulin



doi: 10.15171/ijoem.2019.1629


 pISSN: 2008-6520
 eISSN: 2008-6814

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